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Clobetasol propionate
Product Name: Clobetasol propionate
CAS No.: 25122-46-7
Molecular Formula:C25H32ClFO5
Molecular Weight: 4266.97
Description: Clobetasol propionate, an organic compound with the molecular formula C25H32ClFO5 and molecular weight 466.97, is a white crystalline powder. It is an anti-inflammatory corticosteroid, which can act on various skin diseases. It is applied topically to chronic eczema, neurodermatitis, psoriasis, palmoplantar pustulosis, lichen planus, discoid lupus erythematosus and other pruritic and non-infectious inflammatory skin diseases that are effectively treated with topical glucocorticoids.
Application: Clobetasol propionate is a synthetic and highly effective topical glucocorticoid drug. It has strong anti-inflammatory, anti-pruritic and capillary constricting effects, and also has the effect of inhibiting cell mitosis, which can effectively penetrate into the skin stratum corneum.
Specification:

Item

Specification

Appearance

White or almost white crystalline powder

Solubility

Practically insoluble in water,slightly soluble in benzene and diethyl ether, sparingly soluble ethanol,soluble in acetone and in dimethyl sulfoxide,in chloroform,in methanol and in dioxane.

Identification

IR :Conforms to the CRS spectrum.

Specific rotation

+98¡ã ~ +1049

Melting point

About 196¡ãC

Loss on drying

<2.0%

R esidue on ignition

¡Ü0.1%

Heavy metals

¡Ü20ppm

Related Substances(HPLC)

Any other Impurity¡Ü1.0%

 

Total Impurities ¡Ü2.5%

Organic volatile impurity

Tetrahydrofuran¡Ü720ppm

 

Methanol¡Ü3000ppm

 

N,N-dimethylformamide¡Ü880ppm

 

Pyridine¡Ü200ppm

 

Dichloromethane¡Ü600ppm

 

Ethanol¡Ü5000ppm

 

Acetone¡Ü5000ppm

Purity

97.0%~102.0%

 
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